By Gail Balfour, Muscular Dystrophy Canada
Late last year, a breakthrough study out of Ottawa made headlines around the globe as the first to show that Duchenne muscular dystrophy (DMD) directly affects muscle stem cells – findings that are already changing long-held beliefs around the causes of the disease.
The study, entitled “Dystrophin expression in muscle stem cells regulates their polarity and asymmetric division” was published in Nature Medicine on November 16, 2015. The research concluded that muscle wasting in DMD not only is caused by myofiber fragility, but also is made worse by impaired regeneration due to satellite cell dysfunction. (more…)